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Antimicrobial peptides, which are categorized by homologous structural motifs, are effector molecules of innate immunity with direct antimicrobial activity and multiple other functions.The most prominent families are defensins and cathelicidins.These peptides are expressed in the granules of several types of leukocytes and in a wide variety of tissue types [1].Peptide antibiotics of the cathelicidin family are characterized by a highly conserved signal sequence and proregions ("cathelin" = cathepsin L inhibitor),
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Kaneider et al. (2007) studied this question.
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