Biomimetic phosphorylcholine (PC) groups were introduced onto material surfaces in order to improve the hydrophilicity and in this way the hemocompatibility of polycarbonateurethanes (PCUs). Surface‐initiated atom transfer radical polymerization (SI‐ATRP) of 2‐methacryloyloxyethyl phosphorylcholine (MPC) initiated by irradiation with ultraviolet (UV) light created polymer brushes having PC side groups. Fourier transform infrared (FTIR), X‐ray photoelectron spectroscopy (XPS), scanning electrical microscopy (SEM) and water contact angle were used to characterize the chemical and physical properties of the modified PCU surfaces. The PC‐grafted PCU surfaces showed a significantly higher hydrophilicity as indicated by low water contact angles when compared with original PCU. The in vitro hemocompatibility of the PC‐grafted PCU surfaces was evaluated by platelet adhesion tests. The PCU surfaces modified with phosphorylcholine zwitterionic brushes showed effective resistance for platelet adhesion and high hemocompatibility. These PC‐grafted PCU materials might be potentially applied in blood‐contacting materials or devices due to their good mechanical and hemocompatible properties.
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Feng et al. (2011) studied this question.
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