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Observational study uncovers distinct cognitive and physical fatigue trajectories in relapsing-remitting multiple sclerosis, indicating baseline clinical and MRI markers predict worsening symptoms.
Fatigue is one of the most disabling symptoms of multiple sclerosis (MS), yet its longitudinal trajectories and determinants remain poorly characterized. We aimed to identify trajectories of cognitive and physical fatigue in relapsing-remitting MS (RRMS) and to determine baseline clinical and MRI predictors of worsening fatigue.
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Cruciani et al. (2026) studied this question.
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