One hundred and five rabbits were immunized with a streptococcal group A or C vaccine. An anti‐antibody production in relation to the antistreptococcal antibody production was measured by two methods, the latex fixation test and the sensitized sheep erythrocyte test (the Waaler‐Rose test). The anti‐antibody production was correlated to the amount of precipitating and agglutinating antistreptococcal antibodies, antibody restriction, and γ‐globulin allotypes within the a locus. Anti‐antibodies measured by the Waaler‐Rose test showed no correlation with any of the variables mentioned. The anti‐antibody production measured by the latex fixation test showed a correlation with antibody restriction; that is, a positive latex reaction was found in a higher percentage of rabbits with a homogeneous or restricted heterogeneous antibody response to streptococcal carbohydrate antigens than in rabbits with a heterogeneous antibody response. Possible mechanisms underlying the production of anti‐antibodies are discussed.
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Bent Aasted (1974) studied this question.
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