Synthetic study demonstrates efficient total synthesis of (+)-psychotrimine via late-stage nickel-photoredox C–N coupling, indicating a robust route to complex pyrroloindole alkaloids.
An efficient strategy for the total syntheses of architecturally complex alkaloids, (+)-psychotrimine (1), and formal synthesis of (+)-psychotetramine (2) has been achieved via late-stage Ni(II)-photoredox N-arylation. The method involves the formation of the key building blocks using mild indole addition to bromopyrroloindole and their assembly into the oligomeric hexahydropyrrolo[2,3-b]indole scaffolds via a blue LED-mediated metallaphotoredox-enabled C–N coupling reaction.
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Khatua et al. (2026) studied this question.
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