Case report reveals positive LINC00518 and PRAME expression in a benign pediatric congenital nevus, highlighting pitfalls of unvalidated non-invasive molecular testing.
Small and medium sized congenital melanocytic nevi (CMN) have an overall low risk of malignant potential. This case demonstrates a pediatric patient with a small CMN positive for LINC00518 ( LINC ) and preferentially expressed antigen in melanoma ( PRAME ) on a non‐invasive molecular test not yet validated in children. Although her nevus had not evolved, the availability of a molecular test and curiosity ultimately raised concern about this otherwise reassuring, stable CMN. This demonstrates the pitfalls of non‐invasive testing in pediatric patients with CMN.
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Bitar et al. (2026) studied this question.
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