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August 19, 2026Biophysical ReviewsOpen Access

Field coupling as an interpretative framework for peptide–membrane interactions

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Authors

LNLúcio Otávio Nunes

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Overview

Theoretical analysis establishes a field-coupling framework for peptide–membrane interactions, indicating a structured approach to classify and predict antimicrobial peptide states.

Key Points

  • To develop a unified, regime-based operational framework that connects surface-bound, inserted, and intermediate states in peptide–lipid membrane interactions.
  • Formulated a conceptual model organizing interactions by interfacial electrostatic coupling, hydrophobic-core coupling, and mixed coupling contributions.
  • Integrated key physicochemical variables (charge distribution, hydrophobic moment, bilayer thickness, and lipid saturation) with computational and experimental observables.
  • Established distinct operational regimes categorized into surface-bound, inserted/core, carpet-like, barrel-stave, and mixed/toroidal states based on polar and nonpolar interaction predominance.
  • Generated conditional and falsifiable mechanistic predictions relating structural observables—such as insertion depth, water penetration, membrane thinning, and oligomerization—to transition states across diverse peptide–membrane systems.

Cite This Study

Lúcio Otávio Nunes (2026) studied this question.

synapsesocial.com/papers/6a85643903308d306e2d7e55https://doi.org/10.1007/s12551-026-01451-w
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