Why the study?
Enteroviruses lack effective antiviral therapeutics, and understanding how cellular proteins like GBF1 support viral infection is needed to develop broad-spectrum antivirals.
Understanding how GBF1 supports poliovirus replication may inform the development of broad-spectrum antiviral therapeutics for enteroviruses.
May guide selective antiviral development for enteroviruses; leaves open translation from animal models to human use.
Enteroviruses are a vast group of viruses associated with diverse human diseases, but only two of them could be controlled with vaccines, and effective antiviral therapeutics are lacking. Here, we investigated in detail the contribution of a cellular protein, GBF1, in the replication of poliovirus, a representative enterovirus. GBF1 supports the functioning of cellular membrane metabolism and is recruited to viral replication complexes upon infection. Our results demonstrate that the virus requires a limited subset of the normal GBF1 functions and reveal the elements of GBF1 essential to support viral replication under different conditions. Since diverse viruses often rely on the same cellular proteins for replication, understanding the mechanisms by which these proteins support infection is essential for the development of broad-spectrum antiviral therapeutics.
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Viktorova et al. (2019) studied this question.
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