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A dose-response curve for the leishmanicidal activity of single doses of sodium stibogluconate has been obtained. A linear relationship has been shown to exist between the logarithm of the dose and the logarithm of the ratio of the parasite counts in spleen smears before and after treatment. 2. The effects upon the results of initial degree of infection, body weight, sex, and the size of the spleen have been considered. 3. The effect of allowing the drug to act for varying lengths of time before assessing the results has been investigated. A period of 1 week appears to be most suitable for the testing of antimony compounds.
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L Goodwin (1945) studied this question.
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