Information concerning the secondary isotope rate effect caused by deuterium substitution on the carbon atom next to the reaction center in carbonium ion type reactions is reviewed, and then some other examples of secondary deuterium isotope effects in organic chemistry are summarized. Some new results on isotope effects in some enzyme-catalyzed hydrogen-transfer reactions are also given. (P.C.H.)
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Shiner et al. (1960) studied this question.
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