January 1, 1973The Japanese Journal of PhysiologyOpen Access

Desensitization of Smooth Muscle Cells in the Guinea Pig Taenia Coli to Prolonged Application of Carbachol

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Structured PICO

Population

Guinea pig taenia coli smooth muscle cells

Intervention

Prolonged application of carbachol (10-5 g/ml; 5.5×10-5 M)

Comparator

Various modified Krebs solutions (reduced Na, excess Ca, reduced Ca, reduced Cl, excess K), procaine (1 mM), and hypertonic Krebs solution

Outcome

Electrical and mechanical properties (membrane potential, membrane resistance, and contracture)surrogate

Prolonged carbachol application induces desensitization in guinea pig taenia coli smooth muscle, characterized by membrane repolarization and relaxation, which is modulated by ionic concentrations and procaine.

Discussion

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Implication

Hypothesis-generating in isolated guinea pig smooth muscle; clinical translation to human tissues or therapies remains untested.

Cite This Study

MAGARIBUCHI et al. (1973) studied this question.

synapsesocial.com/papers/6a856f008018c50ef23da281 https://doi.org/10.2170/jjphysiol.23.447

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Desensitization of Smooth Muscle Cells in the Guinea Pig Taenia Coli to Prolonged Application of Carbachol

Structured PICO

Discussion

Implication

Cite This Study

Desensitization of Smooth Muscle Cells in the Guinea Pig Taenia Coli to Prolonged Application of Carbachol

Structured PICO

Discussion

Implication

Cite This Study

Also Consider

Also Consider