Molecular analysis reveals altered solvent residence times around SNase, indicating urea displaces protective TMAO molecules from the protein surface.
O) solvent mixtures than in the binary ones. This is consistent with a recent observation that the fraction of TMAO near the protein decreases in the presence of urea. From the analysis of the decay of the number of particles initially located in the region of the first peak of the distribution function of solvent molecules around the protein, we estimated that about 20 water molecules and 6-7 urea molecules stay near the protein for more than 1000 ps.
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Voloshin et al. (2019) studied this question.
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