NETosis – Does It Really Represent Nature’s “Suicide Bomber”?

NETosis is a term that evolved following publication of an original article supposedly describing a novel form of programed neutrophil death that resulted in the formation of neutrophil extracellular traps (NETs) (1). NETosis was subsequently added to the cell death classifications, almost joining the ranks of other, better documented pathways, such as apoptosis, necroptosis, and autophagic cell death (2). Fuchs et al.’s (1) article seems to NETosis converts to be so seminal that reviewers deny publication to manuscripts in this area, which fail to reference it [Ref. (3); see Supporting Information; Peer Review Correspondence: URL: Link 1].