Instrument‐independent database for collisionally activated dissociation in radiofrequency‐only quadrupoles. Single‐collision versus multiple‐collision conditions

The collisionally actived dissociation (CAD) of the acetone cation ( m / z 58) and of the acetyl cation ( m / z 43) from acetone were studied under single‐collision and multiple‐collision conditions. A kinetics‐based measurement protocol developed at the National Institute of Standards and Technology was used to measure the CAD spectra (i.e., the product distributions (branching ratios) of the CAD fragment ions). A protocol is proposed for a second interlaboratory round robin to explore the feasibility (or lack thereof) of measuring standardized, instrument‐independent CAD spectra under multiple‐collision conditions.