Peptic digestion of fraction III from papain-digested rabbit serum gamma-globulin produces a variety of smaller fragments. Some are too large to pass through a dialysis bag, and these retain the capacity to precipitate with antiserum to rabbit gamma-globulin. Others pass through the bag and fail to precipitate with antibody, but they can inhibit the precipitation of antibody with fraction III. This indicates that antigenic determinants of the gamma-globulin molecule are carried in these fragments.
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Joel W. Goodman (1963) studied this question.
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