Plasma samples from gnotobiotic pups infected with R252 canine distemper virus at 7 days of age contained free infective virus when titrated on canine pulmonary macrophage cultures. Virus was detected 7 days after infection and increased thereafter. Platelets may be involved in leukocyte-free viremia. The present study indicated that the method of dissemination of the virus in vivo involves plasma and canine distemper virus-infected leukocytes.
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Krakowka et al. (1980) studied this question.