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Conformational equilibria of 1,2-dichloroethane, 1-chloro-2-fluoroethane, and β-chloropropionitrile have been investigated in various solvents by using the polarizable continuum model (PCM). Two approaches for the evaluation of trans/gauche free energy differences have been compared: (a) the use, together with experimental intensities, of calculated infrared absorption coefficients and Raman scattering cross sections proper for each solvent; (b) the use of ab initio B3LYP/6-311+G** energy calculations in solution. The agreement between the two approaches is good. The importance of using absorption coefficients and Raman scattering factors proper for each solvent is discussed.
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Cappelli et al. (2001) studied this question.
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