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Although there is little evidence that melatonin may have a direct antimitotic effect on various cells, it has been shown that this pineal compound may influence the cell proliferation of either normal or neoplastic cells. Therefore, the influence of melatonin on the mitotic activity of regenerating adrenal cortex of rats was studied. The mitotic activity was counted in the adrenal cortex or rats on days 2, 7, and 12 following enucleation of the adrenals. Melatonin did not influence the mitotic activity of regenerating adrenal cortex in the rat.
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Karasek et al. (1987) studied this question.
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