Key result
Oral nifedipine required less time to achieve target blood pressure and fewer doses compared to intravenous labetalol for treating acute severe hypertension in pregnancy.
Why the study?
To compare oral nifedipine and intravenous labetalol in the treatment of acute severe hypertension in pregnancy.
Does oral nifedipine reduce the required time to achieve target blood pressure compared to intravenous labetalol in pregnant women with acute severe hypertension?
Meta-Analysis
Does oral nifedipine reduce the required time to achieve target blood pressure compared to intravenous labetalol in pregnant women with acute severe hypertension?
Oral nifedipine may be a more efficient option than intravenous labetalol for treating acute severe hypertension in pregnancy, as it requires less time and fewer doses to achieve target blood pressure.
Supports oral nifedipine as a practical alternative to IV labetalol in severe pregnancy hypertension; reinforces Level 1 evidence for its use.
AIM: To compare oral nifedipine and intravenous labetalol in the treatment of acute severe hypertension in pregnancy (SHP). METHODS: The primary outcomes were the required time to achieve target blood pressure (RTATBP), systolic blood pressure (SBP) and diastolic BP (DBP) after treatment, secondary outcomes were the number of doses (NoD) and adverse events (AEs). RESULTS: There was no difference between oral nifedipine and intravenous labetalol in SBP, DBP, and AE. However, oral nifedipine provided less RTATBP and NoD. CONCLUSION: Oral nifedipine was associated with less RTATBP and NoD and otherwise did not differ from intravenous labetalol.
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Ou et al. (2023) conducted a meta-analysis in acute severe hypertension in pregnancy (SHP). Oral nifedipine vs. Intravenous labetalol was evaluated on required time to achieve target blood pressure (RTATBP), systolic blood pressure (SBP) and diastolic BP (DBP) after treatment. Oral nifedipine required less time to achieve target blood pressure and fewer doses compared to intravenous labetalol for treating acute severe hypertension in pregnancy.
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