Effect of Reserpine on the Adrenal Medulla of Sheep

The changes found in the sheep adrenal medulla on reserpine treatment were, though more pronounced, very similar to those found on indirect stimulation with insulin induced hypoglycemia. On both treatments the mechanism holding the equivalent amounts of amines and adenosinephosphates within the medullary granules is affected in such a way that the amines are released and the adenosinephosphates are broken down and/or released at the same time. In neither case do amines or adenosinephosphates accumulate in the extragranular cytoplasm and the adenine moiety of these phosphates is rapidly disposed of.