Preliminary studies on the carbohydrate-rich fractions of ox serum

THE LIBERATION OF GLUCURONIC ACID 5 administration of glucuronidogenic compounds to animals increased the glucuronidase content of certain tissues (Fishman, 1940; Fishman & Fishman, 1944). As an explanation of his experimental data, it would seem at least equally plausible to suppose that 'f-glucuronidase' acts purely as a hydrolytic enzyme in the body, and that increase in the amount of enzyme in an organ occurs in response to the presence of excess glucuronide formed from the aglycone administered. The work of Mills (1946), who found that splenectomized rabbits fed with menthol conjugated larger fractions with glucuronic acid than normal, could be more readily explained by the latter theory.