What question did this study set out to answer?

To develop a practical, ligand-accelerated cobalt catalytic system for the aerobic diamination of 1,1-disubstituted alkenes with free anilines and elucidate the reaction mechanism.

August 19, 2026Synthesis

Diamine ligand for Cobalt-Catalyzed Aerobic Diamination of 1,1-disubstituted Alkenes with Aniline

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Authors

ZLZhiqiang LiSichuan University SXShubo XingXi'an Jiaotong University XFXiaoming FengChengdu University

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Implication

Mechanistic study demonstrates efficient aerobic alkene diamination via a simple cobalt iodide-diamine catalytic system, indicating a practical pathway to vicinal diamines.

Key Points

To develop a practical, ligand-accelerated cobalt catalytic system for the aerobic diamination of 1,1-disubstituted alkenes with free anilines and elucidate the reaction mechanism.
Implemented a catalytic system combining an accessible cobalt(II) iodide precursor with a diamine ligand to perform aerobic diamination on 1,1-disubstituted alkenes using anilines.
Performed density functional theory (DFT) calculations to investigate reaction intermediates, spin state crossovers, and carbon-nitrogen bond formation pathways.
Established that an in situ generated Co(III) species acts as the active catalyst, replacing the need for complex pre-catalysts.
Revealed computationally that the first C-N bond forms via a spin center shift mechanism, while the second C-N bond forms through one-electron reductive elimination rather than radical substitution.

Cite This Study

Li et al. (2026) studied this question.

synapsesocial.com/papers/6a858aaf03308d306e2d7ffc https://doi.org/10.1055/a-2852-2687

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Implication

Mechanistic study demonstrates efficient aerobic alkene diamination via a simple cobalt iodide-diamine catalytic system, indicating a practical pathway to vicinal diamines.

Diamine ligand for Cobalt-Catalyzed Aerobic Diamination of 1,1-disubstituted Alkenes with Aniline

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Implication

Key Points

Cite This Study

Diamine ligand for Cobalt-Catalyzed Aerobic Diamination of 1,1-disubstituted Alkenes with Aniline

Discussion

Member takes

Implication

Key Points

Cite This Study

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