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March 1, 1988Annals of the New York Academy of Sciences

Pathophysiology of Cardiomyocytesa

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Population

Isolated cardiomyocytes

Comparison

Ca2+ antagonists vs Comparison between slow Ca2+ channel blockers…

Design

Preclinical

Authors

ΜBΜ. BorgersCross-Cutting CardiologyLDLuc Ver DonckJohnson & Johnson (United States)GVG VandeplasscheNovartis (Switzerland)

Discussion

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Implication

Challenges assumption that slow channel blockade prevents Ca2+ overload; hypothesis-generating for non-slow-channel drugs in experimental cardioprotection.

Structured PICO

P
Population
Isolated cardiomyocytes
I
Intervention
Ca2+ antagonists (verapamil, nifedipine, nicardipine, diltiazem, cinnarizine, flunarizine, lidoflazine, and mioflazine)
C
Comparator
Comparison between slow Ca2+ channel blockers and non-slow-channel-blocking drugs
O
Outcome
Cellular degeneration and Ca2+ overloadsurrogate

Non-slow-channel-blocking calcium antagonists provide superior protection against cellular degeneration and calcium overload in isolated cardiomyocytes compared to slow channel blockers.

Cite This Study

Borgers et al. (1988) studied this question.

synapsesocial.com/papers/6a858ec6beaf5c5b091090cdhttps://doi.org/10.1111/j.1749-6632.1988.tb33384.x
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