Key result
A nomogram combining tumor location, preoperative albumin, lymphocytes, neutrophil-to-lymphocyte ratio, and superior mesenteric artery calcium score accurately predicted postoperative anastomotic leakage with a C-index of 0.913.
Why the study?
Anastomotic leakage is a serious complication after colorectal cancer surgery affecting quality of life and prognosis, and a nomogram combining inflammatory-nutritional and abdominal aorta calcium indices was needed to predict this risk.
Cohort (n=292)
No
A novel nomogram incorporating tumor location, inflammatory-nutritional indices, and superior mesenteric artery calcium score can effectively predict the risk of anastomotic leakage after colorectal cancer surgery.
May aid preoperative risk stratification in colorectal surgery; hypothesis-generating and requires prospective validation.
Background: Anastomotic leakage is a serious complication after colorectal cancer surgery, which affects the quality of life and the prognosis. This study aims to create a novel nomogram to predict the risk of anastomotic leakage for patients with colorectal cancer based on the preoperative inflammatory-nutritional index and abdominal aorta calcium index. Methods: 292 patients at Tianjin Medical University General Hospital (Tianjin, China) from January 2018 to October 2021 who underwent colorectal cancer surgery with a primary anastomosis were retrospectively reviewed. A nomogram was constructed based on the results of multivariate logistic regression model. The calibration curves and receiver operating characteristic curves were used to verify the efficacy of the nomogram. A nomogram was constructed based on the results of the multivariate analysis, and the C-index of the calibration curves was 0.913 (95%CI: 0.870-0.957) in the training cohort and 0.840 (95%CI: 0.753-0.927) in the validation cohort. Conclusion: The nomogram, combining basic variables, inflammatory-nutritional index and abdominal aorta calcium index, could effectively predict the possibility of postoperative anastomotic leakage for patients with colorectal cancer, which could guide surgeons to carry out the appropriate treatment for the prevention of anastomotic leakage.
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Zhang et al. (2023) conducted a cohort in Colorectal cancer (n=292). Preoperative inflammatory-nutritional index and abdominal aorta calcium index was evaluated on Predictive accuracy for postoperative anastomotic leakage (training cohort) (C-index 0.913, 95% CI 0.870-0.957). A nomogram combining tumor location, preoperative albumin, lymphocytes, neutrophil-to-lymphocyte ratio, and superior mesenteric artery calcium score accurately predicted postoperative anastomotic leakage with a C-index of 0.913.
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