Key result
Aging drives structural and functional changes in the mitral valve, and understanding these mechanisms is crucial for enhancing diagnostic and therapeutic strategies to reduce age-related valve dysfunction.
Why the study?
The aging process notable effects on mitral valve structure and function, and understanding these mechanisms is crucial for enhancing diagnostic and therapeutic strategies.
Understanding the mechanisms driving mitral valve aging is crucial for enhancing diagnostic and therapeutic strategies to reduce age-related valve dysfunction.
Aging alters mitral valve structure and function; leaves open age-specific management strategies pending prospective validation.
The aging process can have notable effects on the mitral valve. During life, the mitral valve undergoes various changes that can impact its structure and function. The purpose of this review is to present a comprehensive overview of the literature published up to February 2024 in the Medline database regarding the impact of aging on the mitral valve. The studies were combined with the personal experience of the authors. Until 2024, out of the 12,189 publications that deal with the mitral valve in elderly individuals, 308 refer to mitral valve aging. After reviewing these data, we selected and analyzed the 73 most informative works regarding the age-related transformation of the mitral valve. Understanding the mechanisms driving the aging of the mitral valve is crucial for enhancing diagnostic and therapeutic strategies for reducing age-related valve dysfunction and the subsequent cardiovascular complications.
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Opris et al. (2024) conducted a review in Mitral valve aging (n=73). Aging was evaluated on Age-related transformation of the mitral valve. Aging drives structural and functional changes in the mitral valve, and understanding these mechanisms is crucial for enhancing diagnostic and therapeutic strategies to reduce age-related valve dysfunction.
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