This book, with 741 pages, is the first comprehensive and thorough presentation of physiology and biochemistry of the skin in the English language and should be on the desk or available for reference to any internist as well as to dermatologists and other physicians or research workers interested in the subject or in the close relationship that physicochemical changes in the skin bear to internal or systemic disease. Whereas Dr. Rothman in the foreword stated, "The main purpose of this book is to serve dermatological research," there is a great deal in the book that is of fundamental basic character, which the clinician should be familiar with, let alone a scientist working on some problem in medicine as a whole. There are numerous references to the physicochemical aspects of various dermatoses often associated with systemic disease. The author has, however, purposely refrained from making the book a text on clinical
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A 1955 study studied this question.