Key result
Deletion of Kv10.1 in mice does not show a marked phenotype, displaying only mild hyperactivity and longer-lasting haloperidol-induced catalepsy, supporting its potential as a cancer target.
Population
Kv10.1 (Eag1) knockout mice (generated by deletion of exon 7 of the KCNH1 gene)
Comparison
Kv10.1 gene knockout vs Wild-type mice
Design
Preclinical
Authors
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Supports Kv10.1 blockade tolerability in mice; leaves open human safety and efficacy for cancer targeting.
Deletion of Kv10.1 in mice does not result in a marked phenotype, suggesting that Kv10.1 blocking techniques for cancer treatment may be well tolerated.
Ufartes et al. (2013) studied this question. Kv10.1 (Eag1) knockout vs. Wild-type genotypes was evaluated on Behavioural and functional characterization. Deletion of Kv10.1 in mice does not show a marked phenotype, displaying only mild hyperactivity and longer-lasting haloperidol-induced catalepsy, supporting its potential as a cancer target.
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