Key result
Recruitment and activation of thermogenic brown and beige fat, through both UCP1-dependent and independent mechanisms, offer potential therapeutic strategies to counteract obesity and metabolic disorders.
Why the study?
Thermogenic fat can convert energy into heat and may target metabolic syndromes like obesity and type 2 diabetes, prompting a review of its mechanisms, including UCP1-independent adaptive thermogenesis and beiging.
Understanding the mechanisms of brown and beige fat recruitment, including UCP1-independent pathways and 'beiging', offers potential therapeutic targets for obesity and metabolic syndromes.
Brown and beige adipose tissues possess the remarkable capacity to convert energy into heat, which potentially opens novel therapeutic perspectives targeting the epidemic of metabolic syndromes such as obesity and type 2 diabetes. These thermogenic fats implement mitochondrial oxidative phosphorylation and uncouple respiration to catabolize fatty acids and glucose, which leads to an increase in energy expenditure. In particular, beige adipocytes that arise in white adipose tissue display their thermogenic capacity through various noncanonical mechanisms. This review aims to summarize the general overview of thermogenic fat, especially including the UCP1-independent adaptive thermogenesis and the emerging mechanisms of "beiging", which may provide more evidence of targeting thermogenic fat to counteract obesity and other metabolic disorders in humans.
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Wang et al. (2021) conducted a review in Obesity and metabolic disorders. Thermogenic fat recruitment (brown and beige fat activation) was evaluated. Recruitment and activation of thermogenic brown and beige fat, through both UCP1-dependent and independent mechanisms, offer potential therapeutic strategies to counteract obesity and metabolic disorders.
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