Key result
Cardiovascular risk factors including obesity, high blood pressure, oxidative stress, and microalbuminuria were significantly associated with vascular dysfunction (p < 0.05).
Why the study?
There is a paucity of information on the relationship between vascular dysfunction and cardiovascular risk factors in children of African ancestry.
Cross-Sectional
Yes
In South African children of African ancestry, vascular dysfunction is associated with obesity, high blood pressure, oxidative stress, and microalbuminuria.
May support vascular screening in obese hypertensive children; extends associations to African-ancestry youth but remains hypothesis-generating.
Vascular dysfunction is known to be an initiator of the development and progression of cardiovascular diseases (CVDs). However, there is paucity of information on the relationship of vascular dysfunction with cardiovascular risk factors in children of African ancestry. This study investigated the relationship between cardiovascular risk factors and vascular function in South African children of African ancestry. A cross-sectional study on 6–9-year-old children in randomly selected rural and urban schools of the Eastern Cape Province of South Africa was conducted. General anthropometric indices were measured, followed by blood pressure (BP) measurements. The pulse wave velocity (PWV) was measured using a Vicorder. Albumin to creatinine ratio (ACR), asymmetric dimethylarginine (ADMA), 8-hydroxy-2deoxyguanosine (8-OHdG) and thiobarbituric acid reactive substance (TBARS) were assayed in urine. Children from urban settings (10.8%) had a higher prevalence of overweight/obesity than their rural counterparts (8.5%) while the prevalence of elevated/high blood pressure was higher in rural (23.2%) than urban children (19.0%). Mean arterial blood pressure (MAP) and diastolic blood pressure (DBP) increased with increasing PWV (p < 0.05). Body mass index (BMI), diastolic blood pressure (DBP) and mean arterial blood pressure (MAP) positively associated (p < 0.05) with PWV. Creatinine, albumin and ACR significantly (p < 0.005) increased with increasing ADMA. ADMA associated positively (p < 0.05) with creatinine and 8-OHdG. In conclusion, vascular dysfunction was associated with obesity, high blood pressure, oxidative stress and microalbuminuria in South African children of African ancestry.
No takes yet. Share an insight, caveat, or question.
Matjuda et al. (2021) conducted a cross-sectional in Cardiovascular risk factors and vascular dysfunction. Cardiovascular risk factors (obesity, high blood pressure, oxidative stress, microalbuminuria) was evaluated on Vascular dysfunction (measured by pulse wave velocity and ADMA) (p=< 0.05). Cardiovascular risk factors including obesity, high blood pressure, oxidative stress, and microalbuminuria were significantly associated with vascular dysfunction (p < 0.05).
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: