An indirect strategy was needed for the first synthesis of a labile dNDP-3-keto sugar, the title compound 2. D-Glucose is converted into methylene phosphate 1, which after ozonolysis and linkage of thymidine monophosphate, provides 2. According to present knowledge the target compound is an important intermediate in the biosynthesis of dideoxy, trideoxy, aminodeoxy, and branched sugars.
No takes yet. Share an insight, caveat, or question.
Müller et al. (1995) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: