The study quantifies the geometric variability of the human aortic bifurcation using MRI, which may relate to variable predispositions to atherosclerosis.
May link aortic bifurcation planarity variability to atherosclerosis risk; hypothesis-generating and requires prospective validation.
The susceptibility of vascular branches to atherosclerosis is believed to be due in part to the unusual fluid dynamic environments that the vessel wall experiences in these regions. As vascular geometry is a primary determinant of the local haemodynamic environment, it is of interest to quantitate the geometric features of vascular branches and their variability. The present research focusses on branch planarity, using axial magnetic resonance images of the aortic bifurcations of 20 healthy subjects. The in vivo images were processed to obtain vector representations of the vessel axes at the bifurcation, from which the planarity of the bifurcation was derived using a novel robust definition. Three-dimensional reconstructions of the bifurcations were rendered using computer graphics techniques to demonstrate the variability of the planarity of this region of the vasculature; this variability might be related to variable predispositions to atherosclerosis at the aortic bifurcation.
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Friedman et al. (1998) studied this question.
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