8-Deoxylankolide from a Lankamycin Producing Streptomyces spp.

6-Deoxyerythronolide B (1) which is isolated from the culture broth of Saccharopolyspora erythraea has been proven to be an intermediate in the biosynthesis of erythromycins.1} Actually, 6-deoxyerythronolide B, derived from propionyl CoA and six equivalents of methylmalonyl CoA, is oxidized by molecular oxygen to erythronolide B (2), which is then converted to the erythromycins.2~7) Lankamycin, which was first isolated from Streptomyces violaceoniger in 19608) has an