// Xue Han 1, * , Li Xiao 2, * , Yao Yu 3 , Yu Chen 2 and Hai-Hua Shu 1 1 Department of Anesthesiology, Guangdong Second Provincial General Hospital, Guangzhou, China 2 Department of Anesthesiology, First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China 3 Department of Anesthesiology, Second Affiliated Hospital of Dalian Medical University, Dalian, China * These authors contributed equally to this work Correspondence to: Xue Han, email: oncoscience@163.com Keywords: alcohol consumption, meta-analysis, gastric cancer, dose-risk relation Received: March 02, 2017 Accepted: June 30, 2017 Published: July 12, 2017 ABSTRACT We performed this meta-analysis to explore the precise quantification relationship between alcohol consumption and gastric cancer and to provide evidence for preventing gastric cancer. We searched PubMed, Embase, and Web of Science for articles published up to December 2016, and identified 23 cohort studies that included a total population of 5,886,792 subjects. We derived meta-analytic estimates using random-effects models, taking into account correlations between estimates. We also investigated the dose–response relationship between gastric cancer risk and alcohol consumption. We found that alcohol consumption increased gastric cancer risk, where the summary risk ratio was 1.17 (95% confidence interval (CI): 1.00–1.34; I 2 = 79.6%, p < 0.05. The dose–response analysis showed that every 10 g/d increment in alcohol consumption was associated with 7% increased gastric cancer risk (95% CI 1.02–1.12; I 2 = 28.9%, p = 0.002). This meta-analysis provides evidence that alcohol consumption is an important risk factor of the incidence of gastric cancer.
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