Key result
Enterovirus A71 subgenogroup C4 was the predominant strain detected in a 2018 upsurge of severe hand, foot and mouth disease cases in Vietnam, accounting for 90% of sequenced EV-A71 infections.
Why the study?
The re-emergence of enterovirus A71 subgenogroup C4 raised concern of an impending severe hand, foot and mouth disease outbreak among susceptible young children in Vietnam.
Observational (n=86)
No
The re-emergence of enterovirus A71 subgenogroup C4 in Vietnam in 2018 raises concerns for a severe HFMD outbreak among susceptible young children.
Since January 2018, over 53,000 hospitalisations and six deaths due to hand, foot and mouth disease (HFMD) have occurred across Vietnam with most cases from September onward. In a large tertiary referral hospital, Ho Chi Minh City, enterovirus A71 subgenogroup C4 was predominant, while B5 was only sporadically detected. The re-emergence of C4 after causing a severe HFMD outbreak with > 200 deaths in 2011-12 among susceptible young children raises concern of another impending severe outbreak.
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Nhan et al. (2018) conducted an observational in Hand, foot and mouth disease (HFMD) (n=86). Enterovirus A71 subgenogroup C4 infection was evaluated. Enterovirus A71 subgenogroup C4 was the predominant strain detected in a 2018 upsurge of severe hand, foot and mouth disease cases in Vietnam, accounting for 90% of sequenced EV-A71 infections.
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