Key result
Targeting the orphan nuclear receptor SHP represents a potential therapeutic strategy for metabolic and fibrotic diseases, though clinical data in humans remain insufficient.
SHP represents a promising but early-stage therapeutic target for metabolic syndrome and fibrotic diseases, requiring further human data and inducer discovery.
Clinical adoption of SHP targeting premature; leaves open its viability as a therapeutic target pending human trials.
IMPORTANCE OF THE FIELD: The orphan nuclear receptor small heterodimer partner (SHP; NR0B2) is an atypical nuclear receptor that contains a ligand-binding domain, but lacks the conserved DNA-binding domain. Since its discovery, SHP has been identified as a key transcriptional regulatory factor of genes involved in diverse metabolic pathways. AREAS COVERED IN THIS REVIEW: We performed a Medline/Pubmed search to find published studies on the role of SHP in the regulation of metabolism in the liver, pancreatic islets, blood vessel, and kidney and on the feasibility of using SHP as a therapeutic target in metabolic disease. WHAT THE READER WILL GAIN: In this review, we discuss the function of SHP as regulator of cholesterol, lipid and glucose metabolism, and the role of SHP in metabolic and fibrotic diseases. TAKE HOME MESSAGE: The reviewed studies suggested that SHP could be a major target for therapeutic intervention in metabolic and fibrotic diseases, including metabolic syndrome and its complications. However, for SHP-targeted therapy, there are some outstanding issues, including the small number of known inducers of SHP and the lack of sufficient data in humans.
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Kim et al. (2010) conducted a review in Metabolic and fibrotic diseases. SHP-targeted therapy was evaluated. Targeting the orphan nuclear receptor SHP represents a potential therapeutic strategy for metabolic and fibrotic diseases, though clinical data in humans remain insufficient.
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