Atracurium and McArdle's diseaseMcArdle's disease, glycogenosis V. is a hereditary myopathy caused by a deficiency of the muscle phosphorylase which converts glycogen to lactate.Glycogen therefore accumulates in the muscles and patients suffer from pain on exercise, relieved by rest.Myoglobinuria may occur after severe exercise and.rarely, this may precipitate renal failure.'A 4-year-old boy (weight 18.2 kg) who had been diagnosed as a probable case of McArdle's disease was presented for adenoidectomy.He had a history of cramp-like pains in his legs on exertion, and recurrent chest infections.On examination he had pseudo-
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Rajah et al. (1986) studied this question.