An inhibitory GTP-binding protein may modulate the action of protein kinase C on exocytosis in bovine adrenal medullary cells.
Species differences in GTP analog effects on exocytosis caution against extrapolating to humans; leaves open G-protein modulation of PKC-driven secretion in mammalian adrenal cells.
Exposure of 'leaky' adrenal medullary cells to GTP-y-S inhibits Ca-dependent exocytosis in bovine cells, but stimulates exocytosis in chicken cells. The inhibitory action on bovine cells persists in the presence of TPA suggesting that in this tissue an inhibitory GTP-binding protein may modulate the action of protein kinase C on exocytosis.
No takes yet. Share an insight, caveat, or question.
Knight et al. (1985) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: