The activity of an antibody, like that of an enzyme, appears to be determined by its primary structure (Haber, 1964; Whitney and Tanford, 1965). Amino acid sequences are thus of considerable importance for an understanding of an antibody's specific activity, as well as for evaluating the genetic basis for the great diversity of antibody molecules formed by an individual organism. Can sufficient amounts of pure (i.e., homogeneous) antibodies be obtained for establishment of amino acid sequences in the variable regions of their polypeptide chains—regions of paramount interest for studies of specificity and evaluation of genetic mechanisms?
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Eisen et al. (1967) studied this question.