What question did this study set out to answer?

To determine the frequency of zidovudine-resistant HIV-1 strains and evaluate mother-to-child transmission in infected infants following zidovudine prophylaxis.

June 1, 2001JAIDS Journal of Acquired Immune Deficiency Syndromes

Zidovudine Genotypic Resistance in HIV-1–Infected Newborns in the French Perinatal Cohort

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Authors

BMBernard MasquelierLaboratoire de Microbiologie Fondamentale et Pathogénicité MCMarie‐Laure ChaixInserm MBMarianne BurgardHôpital Necker-Enfants Malades

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Implication

Retrospective study reveals zidovudine resistance mutations in 20% of infected newborns, indicating that drug resistance facilitates mother-to-child transmission.

Key Points

To determine the frequency of zidovudine-resistant HIV-1 strains and evaluate mother-to-child transmission in infected infants following zidovudine prophylaxis.
Conducted a retrospective nucleotide sequence analysis of HIV-1 reverse transcriptase using isolates from 34 infants and 18 maternal plasma samples in the French Perinatal Cohort.
Performed phylogenetic analyses on infant viral isolates to identify HIV-1 subtypes.
Zidovudine resistance mutations were detected in 7 of 34 infants (20%), with evidence of mother-to-child transmission of resistant HIV-1 confirmed in 4 cases.
Phylogenetic analysis identified non-B subtypes in 14 of 34 infant isolates, and resistance-encoding mutations were associated with longer total duration of zidovudine exposure.

Cite This Study

Masquelier et al. (2001) studied this question.

synapsesocial.com/papers/6a85a8de7fcf0fdb395e273d https://doi.org/10.1097/00042560-200106010-00001

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Implication

Retrospective study reveals zidovudine resistance mutations in 20% of infected newborns, indicating that drug resistance facilitates mother-to-child transmission.

Zidovudine Genotypic Resistance in HIV-1–Infected Newborns in the French Perinatal Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

Zidovudine Genotypic Resistance in HIV-1–Infected Newborns in the French Perinatal Cohort

Discussion

Member takes

Implication

Key Points

Cite This Study

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