Key result
A single dose of sildenafil completely prevented rebound pulmonary hypertension after withdrawal of nitric oxide compared to placebo (0% vs 71.4%; p < 0.001).
Why the study?
Does a single dose of sildenafil prevent rebound pulmonary hypertension in ventilated infants and children being weaned from inhaled nitric oxide?
Population
30 ventilated infants and children receiving 10 ppm or greater inhaled nitric oxide, in whom previous…
Comparison
Sildenafil 0.4 mg/kg administered 1 hour before… vs Placebo administered 1 hour before discontinuing…
Design
RCT, Randomized (method not specified)
Follow-up
4 hours after stopping NO
Authors
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Supports pre-withdrawal sildenafil for safer nitric oxide weaning in ventilated children; provides RCT evidence for rebound prevention.
RCT (n=30)
Does a single dose of sildenafil prevent rebound pulmonary hypertension in ventilated infants and children being weaned from inhaled nitric oxide?
Absolute Event Rate: 0% vs 71.4%
p-value: p=<0.001
A single dose of sildenafil administered before nitric oxide withdrawal effectively prevents rebound pulmonary hypertension and significantly reduces the duration of mechanical ventilation in infants and children.
Theilen et al. (2006) conducted an RCT in Rebound pulmonary hypertension after withdrawal of nitric oxide (n=30). Sildenafil vs. Placebo was evaluated on Rebound (an increase in PA pressure of 20% or greater, or failure to discontinue NO) (p=<0.001). A single dose of sildenafil completely prevented rebound pulmonary hypertension after withdrawal of nitric oxide compared to placebo (0% vs 71.4%; p < 0.001).
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