Key result
Activation of CXCR7 by TC14012 alleviated cardiac deficiency, reduced infarct size, promoted angiogenesis, and reduced apoptosis in AMI model mice and hypoxic endothelial cells.
Why the study?
Although CXCR7 activation has been shown to protect the heart, its specific role in angiogenesis in the ischemic area after AMI remains unclear.
Does CXCR7 activation improve cardiac function and reduce apoptosis in preclinical models of acute myocardial infarction?
Does CXCR7 activation improve cardiac function and reduce apoptosis in preclinical models of acute myocardial infarction?
CXCR7 activation represents a potential therapeutic target to rescue ischemic myocardium by promoting angiogenesis and reducing apoptosis.
Answers are grounded in this paper and cite their sources.
Supports CXCR7 as target in preclinical AMI; leaves open translation to patients.
Angiogenesis is an important pathway for revascularization of ischemic tissues after acute myocardial infarction (AMI). It is unclear what role CXCR7 plays in angiogenesis in the ischemic area after AMI, although some researchers have shown that the activation of CXCR7 protectsthe heart under those conditions. Here, we hypothesize that the activation of CXCR7 promotes angiogenesis, reduces cell apoptosis and alleviates cardiac deficiency after AMI. C57BL/6 J mice were subjected to AMI and treated with TC14012 (10 mg/kg) for 24 days. HUVECs were cultured in a hypoxic (2% O2) environment to generate a model of hypoxia. CXCR7 was knocked down in HUVECs by sh-CXCR7 transfection, and CXCR7 was activated by TC14012 (30 μM) treatment. The results showed that CXCR7 was downregulated in infarcted heart tissue and hypoxic HUVECs. The global activation of CXCR7 may alleviate the decrease in cardiac function indexes — (ejection fraction and fraction shortening), and reduce infarct size after AMI.. Moreover, CXCR7 activation has been shown to enhance the level of angiogenesis in ischemic heart tissue. In vitro, hypoxia-induced angiogenic functional loss and apoptosis are aggravated by CXCR7 knockdown in HUVECs. Both angiogenic impairment and cell apoptosis are rescued by CXCR7 activation. In conclusion, the present study indicates that activation of CXCR7 plays an important protective role for ischemic cells in hypoxic endothelial cells and AMI model mice by promoting angiogenesis and reducing apoptosis, which suggests that CXCR7 may be a potential therapeutic target to rescue the ischemic myocardium..
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Zhang et al. (2020) studied Acute myocardial infarction. TC14012 (CXCR7 activation) was evaluated on Cardiac function indexes, infarct size, angiogenesis, and apoptosis. Activation of CXCR7 by TC14012 alleviated cardiac deficiency, reduced infarct size, promoted angiogenesis, and reduced apoptosis in AMI model mice and hypoxic endothelial cells.
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