Rats were subjected to restraint of various lengths of time. In the experiments of longer duration ulcers developed whereas in the shorter experiments no ulcers were seen. The aminosugar content of acid polysaccharides in the gastric wall of the glandular stomach were increased slightly in the “pre‐ulcerous” groups and fell sharply to below control values in the ulcer groups. Fractionation of polysaccharides from the ulcer groups showed that the fractions believed to contain connective tissue polysaccharides (chondroitin sulfuric acid and hyaluronic acid) and one of the fractions containing epithelial mucopolysaccharides fell significantly. This effect has also been seen in other studies in dogs after cinchophen feeding. This study shows that the changes in the gastric wall polysaccharides can be affected endogenously without any pharmacological agents.
No takes yet. Share an insight, caveat, or question.
Häkkinen et al. (1966) studied this question.
Synapse has enriched one closely related paper. Consider it for comparative context: