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Three and four-component radical and radical−organometallic processes have been developed that provide a simple access to 2,3-disubstituted piperidinones. Reasonable yield and high stereoselectivities were achieved in a number of cases with three C−C bonds and one C−N bond and up to three stereogenic centers generated in one pot from readily available reagents.
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Godineau et al. (2007) studied this question.
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