In this work, we demonstrated Ni-catalyzed oxidative coupling of unactivated C(sp 3 )–H bonds with terminal alkynes for construction of C(sp 3 )–C(sp) bonds to synthesize alkyl-substituted internal alkynes. Different amides exhibited good compatibility. Preliminary mechanistic studies were conducted to account for this alkynylation.
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Luo et al. (2016) studied this question.
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