Efficient Synthesis of Nucleoside Diphosphate Glycopyranoses

Short and sweet: A new, short synthetic pathway for the synthesis of the enormously important class of nucleoside diphosphate sugars (NDP sugars) was developed using cyclo-saligenyl (cycloSal) nucleosyl phosphate triesters as active ester equivalents that form the target compounds in the presence of anomerically pure pyranose 1-phosphates in high yields (see scheme; T= thymine; X=OAc, H; Y=OH, H).