Key result
Bedside H-FABP measurement demonstrated a higher diagnostic accuracy index (85%) compared to troponin I (65%) and CK-MB (62%) for the early diagnosis of NSTEMI within 6 hours of symptom onset.
Why the study?
Does bedside H-FABP measurement improve the early diagnosis of NSTEMI compared to routine CK-MB and TnI in patients presenting with ischaemic chest pain without ST-elevation?
Population
48 patients admitted to the emergency room within the first 12 hours of onset of ischaemic-type chest pain…
Comparison
Bedside qualitative measurement of heart-type… vs Routine creatine kinase-MB and troponin I tests
Design
Cohort
Follow-up
24 hours
Authors
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May support early NSTEMI detection in chest pain; leaves open need for prospective validation before practice change.
Cross-Sectional (n=48)
No
Does bedside H-FABP measurement improve the early diagnosis of NSTEMI compared to routine CK-MB and TnI in patients presenting with ischaemic chest pain without ST-elevation?
Absolute Event Rate: 85% vs 65%
p-value: p=<0.05
Bedside H-FABP measurement provides higher sensitivity than troponin I for the very early (≤3 hours) diagnosis of NSTEMI in patients presenting with chest pain.
Gerede et al. (2015) conducted a cross-sectional in Non-ST-segment elevation myocardial infarction (NSTEMI) (n=48). Bedside H-FABP measurement vs. Routine creatine kinase-MB (CK-MB) and troponin I (TnI) tests was evaluated on Accuracy index for early diagnosis of NSTEMI (≤ 6 hours) (p=<0.05). Bedside H-FABP measurement demonstrated a higher diagnostic accuracy index (85%) compared to troponin I (65%) and CK-MB (62%) for the early diagnosis of NSTEMI within 6 hours of symptom onset.
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