Key result
Ischemia-modified albumin was an independent risk marker for diabetic ketosis (OR 1.085; 95% CI 1.022-1.152; P=0.008) and was more sensitive than C-reactive protein (AUC 0.917 vs 0.357).
Why the study?
Does serum ischemia-modified albumin or C-reactive protein predict diabetic ketosis in type 2 diabetic patients?
Observational (n=137)
Does serum ischemia-modified albumin or C-reactive protein predict diabetic ketosis in type 2 diabetic patients?
Odds Ratio: 1.085 (95% CI 1.022–1.152)
p-value: p=0.008
Serum ischemia-modified albumin is a sensitive and independent biomarker for predicting diabetic ketosis in patients with type 2 diabetes.
Does not support changing ketosis risk assessment in type 2 diabetes; leaves open ischemia-modified albumin utility pending prospective validation.
OVERVIEW: To investigate whether serum ischemia-modified albumin or C-reactive protein is reliable for predicting type 2 diabetic patients with ketosis. APPROACH: One hundred and four diabetic patients, 48 with diabetic ketosis, and 33 controls were enrolled in the study. Serum ischemia-modified albumin and C-reactive protein were measured and evaluated for their ability to distinguish diabetic ketosis. RESULTS: Compared to the controls, the ischemia-modified albumin and C-reactive protein levels were higher in patients with diabetic ketosis and type 2 diabetes at the baseline. The levels of ischemia-modified albumin were higher in patients with type 2 diabetes than in the controls. C-reactive protein and ischemia-modified albumin levels were reduced after insulin treatment. The level of ischemia-modified albumin was an independent risk marker for diabetic ketosis (OR = 1.085, P = 0.008, 95% CI: 1.022-1.152). Receiver operating characteristic curves revealed that the areas under the curve were 0.917 for the modified albumin and 0.357 for C-reactive protein. CONCLUSION: This study indicates that ischemia-modified albumin was significantly associated with diabetic ketosis and was more sensitive than C-reactive protein in reflecting diabetic ketosis.
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Ma et al. (2012) conducted an observational in Type 2 diabetes with and without ketosis (n=137). Serum ischemia-modified albumin and C-reactive protein levels vs. Controls and diabetic patients without ketosis was evaluated on Diabetic ketosis (OR 1.085, 95% CI 1.022-1.152, p=0.008). Ischemia-modified albumin was an independent risk marker for diabetic ketosis (OR 1.085; 95% CI 1.022-1.152; P=0.008) and was more sensitive than C-reactive protein (AUC 0.917 vs 0.357).
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