Key result
De novo atrial fibrillation during acute myocardial infarction was significantly associated with increased long-term cardiovascular mortality (HR 1.45; 95% CI 1.19-2.57; P<0.001).
Why the study?
The prognosis of patients presenting with de novo AF during acute myocardial infarction has been controversial, and data on long-term outcomes and associated anti-thrombotic strategies were lacking.
Does de novo atrial fibrillation during acute myocardial infarction increase the risk of long-term cardiovascular mortality, and does triple anti-thrombotic therapy improve outcomes in this population?
Population
1372 patients presenting with acute myocardial infarction
Comparison
De novo AF vs without de novo AF, and anti-thrombotic treatment strategies
Design
Prospective registry-based cohort study
Follow-up
Median time of 8.6 years
Authors
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De novo AF post-MI signals higher long-term CV mortality; supports hypothesis-generating benefit of triple therapy but needs RCTs before practice change.
Cohort (n=1,372)
No
Does de novo atrial fibrillation during acute myocardial infarction increase the risk of long-term cardiovascular mortality, and does triple anti-thrombotic therapy improve outcomes in this population?
Hazard Ratio: 1.45 (95% CI 1.19–2.57)
Absolute Event Rate: 62.4% vs 26.6%
p-value: p=< 0.001
De novo atrial fibrillation during acute myocardial infarction is associated with a significantly increased risk of long-term cardiovascular mortality, which may be mitigated by intensified anti-thrombotic treatment.
Hofer et al. (2020) conducted a cohort in acute myocardial infarction (n=1,372). De novo atrial fibrillation vs. No de novo atrial fibrillation was evaluated on Cardiovascular mortality (HR 1.45, 95% CI 1.19-2.57, p=< 0.001). De novo atrial fibrillation during acute myocardial infarction was significantly associated with increased long-term cardiovascular mortality (HR 1.45; 95% CI 1.19-2.57; P<0.001).
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