A study of the release of β-estradiol from d,l-lactide/ε-caprolactone copolymers was performed. The copolymers were used in the form of films (in vitro) and microspheres (in vivo). The dl-lactide content was varied from 50 to 94% in the copolymers studied. It was found that an almost constant rate of β-estradiol release for about 70 days can be achieved by the application of appropriately selected material.
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Buntner et al. (1996) studied this question.
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