We report a generic approach for identification of target proteins of therapeutic molecules using nanoprobes. Nanoprobes verify the integrity of nanoparticle-bound ligands in live cells and pull down target proteins from the cellular proteome, providing very important information on drug targets and mechanisms of action. As an example, target proteins as α-tubulin and HSP 90 have been identified and validated.
No takes yet. Share an insight, caveat, or question.
Li et al. (2011) studied this question.
Synapse has enriched 5 related papers. Consider them for comparative context: